教 授 　中川　貴之　(Takayuki NAKAGAWA)
（和歌山県立医科大学附属病院薬剤部?薬剤部長）

2019年

Koyanagi M, Imai S, Matsumoto M, Iwamitsu Y, Saigo M, Ntogwa M, Hiraiwa R, Ogihara T, Nakagawa T, Matsubara K
「Schwann cell-mediated immune response participates in paclitaxel-induced peripheral neuropathy pathogenesis」
The 49th Annual Meeting of Society for Neuroscience, Neuroscience 2019、2019.10.19-23 (Chicago)

Jin C, Yonezawa A, Yoshimatsu H, Imai S, Koyanagi M, Yamanishi K, Nakagawa S, Omura T, Nakagawa T, Matsubara K
「Slc52a3 gene disruption affected the development of cerebral cortex in mice」
The 49th Annual Meeting of Society for Neuroscience, Neuroscience 2019、2019.10.19-23 (Chicago)

Omura T, Sasaoka M, Hashimoto G, Imai S, Yamamoto J, Sato Y, Nakagawa S, Yonezawa A, Nakagawa T, Tasaki Y, Yano I, Matsubara K,
「Oxicam-derived non-steroidal anti-inflammatory drugs protect against 1-methyl-4-phenyl pyridinium-induced cell death by suppressing of endoplasmic reticulum stress and mitochondrial dysfunction」
The 49th Annual Meeting of Society for Neuroscience, Neuroscience 2019、2019.10.19-23 (Chicago)

Katada Y, Nakagawa S, Nishimura A, Sato Y, Taue H, Matsumura K, Yamamoto S, Yamazaki K, Minakata K, Yano I, Omura Y, Imai S, Yonezawa A, Sato Y, Nakagawa T, Minatoya K, Matsubara K
「The amount of dietary intake affects warfarin sensitivity index after cardiovascular surgery」
79th FIP World Congress of Pharmacy and Pharmaceutical Sciences 2019、2019.9.22-26 (Abu Dhabi)

2018年

Ogihara T, Imai S, Nakagawa T, Matsubara K
「Improvement of vascular impairment by tadalafil, a phosphodiesterase type 5 inhibitor, alleviates and prevents oxaliplatin-induced peripheral neuropathy in mice」
The 17th World Congress on Pain 2018、2018.9.12-16 (Boston)

Ntogwa M, Imai S, Hiraiwa R, Koyanagi M, Nakagawa T, Matsubara K
「Possible involvement of macrophages in pathogenesis of HIV-induced distal sensory neuropathic pain in mice」
The 17th World Congress on Pain 2018、2018.9.12-16 (Boston)

So K, Hiyama H, Yano Y, Imai S, Shirakawa H, Nakagawa T, Kaneko S
「Sensitization of TRPA1 through vascular impairment is involved in cold hypersensitivity induced by diabetes in mice」
The 17th World Congress on Pain 2018、2018.9.12-16 (Boston)

Nakagawa T, Miyake T, Nakamura S, Zhao M, So K, Shirakawa H, Kaneko S
「TRPA1 sensitization to ROS by relief from prolyl hydroxylation contributes to oxaliplatin-induced acute cold hypersensitivity」
The 17th World Congress on Pain 2018、2018.9.12-16 (Boston)

Kaneko S, Nakagawa T
Symposium『Pain Sensor』（Mori Y, Voets T）
「Role of TRPA1 in ischemia/reperfusion-induced painful dysesthesia and oxaliplatin-induced cold hypersensitivity」
The 18th World Congress of Basic and Clinical Pharmacology、2018.7.1-6 (Kyoto)

Nakagawa T, Miyake T, Nakamura S, Zhao M, So K, Shirakawa H, Mori Y, Kaneko S
「Unveiled cold sensitivity of TRPA1 by the prolyl hydroxylation inhibition-induced sensitization to ROS in oxaliplatin-induced acute peripheral neuropathy」
The 18th World Congress of Basic and Clinical Pharmacology、2018.7.1-6 (Kyoto)

Imai S, Miyayama M, Shimizu Y, Asaoka N, Nishitani N, Kaneko S, Nakagawa T, Matsubara K
「Less potent in the hypnotic effect of benzodiazepine associated with decreased GABAergic transmission in the chronic social defeat stress model mouse」
The 18th World Congress of Basic and Clinical Pharmacology、2018.7.1-6 (Kyoto)

Ntogwa M, Imai S, Hiraiwa R, Koyanagai M, Nakagawa T, Matsubara K
「Possible involvement of macrophages in the pathogenesis of HIV-induced distal sensory neuropathic pain」
The 18th World Congress of Basic and Clinical Pharmacology、2018.7.1-6 (Kyoto)

Koyanagai M, Imai S, Matsumoto M, Ogihara T, Nakazato Y, Nakagawa T, Matsubara K
「Direct impairment of Schwann cells by taxanes and platinum derivatives participates in the chemotherapy-induced peripheral neuropathy pathogenesis」
The 18th World Congress of Basic and Clinical Pharmacology、2018.7.1-6 (Kyoto)

Omura T, Matsuda H, Nomura L, Naito M, Nakagawa S, Imai S, Yonezawa A, Nakagawa T, Matsubara K
「Role of ubiquitin ligase HRD1 in a cellular model of Parkinson's disease」
The 18th World Congress of Basic and Clinical Pharmacology、2018.7.1-6 (Kyoto)

Jin C, Yoshimatsu H, Yonezawa A, Yamanishi K, Yao Y, Nakagawa S, Imai S, Omura T, Nakagawa T, Matsubara K
「Disruption of Slc52a3 gene causes abnormalities of energy metabolism and brain development in mice with riboflavin deficiency」
The 18th World Congress of Basic and Clinical Pharmacology、2018.7.1-6 (Kyoto)

Nishitani N, Asaoka N, Kawai H, Shibui N, Nagai Y, Andoh C ,Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S
「Optogenetic manipulation of dorsal raphe serotonergic neurons modulates emotional behaviors in rodents」
The 18th World Congress of Basic and Clinical Pharmacology、2018.7.1-6 (Kyoto)

Nagashima T, Nakagawa T, Kaneko S
「Prevention of antipsychotic-induced hyperglycemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism」
The 18th World Congress of Basic and Clinical Pharmacology、2018.7.1-6 (Kyoto)

Asaoka N, Nishitani N, Kinoshita H, Nagai Y, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S
「An adenosine A_2A receptor antagonist, istradefylline, improves multiple symptoms reflecting obsessive-compulsive disorder in a novel murine model」
The 18th World Congress of Basic and Clinical Pharmacology、2018.7.1-6 (Kyoto)

2017年

Koyanagi M, Imai S, Nakazato Y, Matsumoto M, Ogihara T, Nakagawa T, Matsubara K
「Direct impairment of Schwann cells by taxanes and platinum derivatives is associated with etiologic mechanisms underlying chemotherapy-induced peripheral neuropathy」
The 47th Annual Meeting of Society for Neuroscience, Neuroscience 2017、2017.11.11-15 (Washington DC)

2016年

Nakagawa T, So K, Tei Y, Zhao M, Miyake T, Hiyama H, Shirakawa H, Imai S, Matsubara K, Mori Y, Kaneko S
「Hypoxia-induced sensitization of TRPA1 to reactive oxygen species causes painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice」
16th World Congress on Pain、2016.9.26-30 (Yokohama)

Imai S, Koyanagi M, Nakazato Y, Azimi Z, Kaneko S, Nakagawa T, Matsubara K
「Differential effects of paclitaxel and platinum derivatives on primary cultured Schwann cells participate in the pathogenesis of peripheral neuropathy」
16th World Congress on Pain、2016.9.26-30 (Yokohama)

Isami K, Imai S, Sukeishi A, Nakazato Y, Shirakawa H, Nakagawa T, Matsubara K, Kaneko S
「Differential immune responses depending on genetic heterogeneity contribute to the phenotype of neuropathic pain among mouse strains」
16th World Congress on Pain、2016.9.26-30 (Yokohama)

Miyake T, Nakamura S, So K, Shirakawa H, Nakagawa T, Kaneko S
「Relief from prolyl hydroxylation by oxaliplatin allows TRPA1 to sense noxious cold via transduction of reactive oxygen species signaling」
16th World Congress on Pain、2016.9.26-30 (Yokohama)

Hanai A, Ishiguro H, Sozu T, Tsuda M, Nakagawa T, Imai S, Hamabe Y, Toi M, Arai H, Tsuboyama T
「The effects of frozen glove and sock on paclitaxel-induced peripheral neuropathy among breast cancer patients: matched case-control study: a self controlled clinical trial」
ASCO Annual Meeting 2016、2016.7.3-7 (Chicago, USA)

2014年

Kamei J, Aizawa N, Nakagawa T, Ito H, Sugiyama R, Akiyama Y, Niimi A, Kaneko S, Homma Y, Igawa Y
「In vivo and in vitro functional characteristics of the bladder in mice lacking transient receptor potential melastatin 2 (TRPM2) channel」
International Continence Society 2014、2014.10.20-24 (Rio de Janeiro, Brazil)

2013年

Zhao M, Miyake T, Nakamura S, Shirakawa H, Nakagawa T, Kaneko S
「Mechanisms of TRPA1 activation in oxaliplatin-induced acute peripheral neuropathy」
The 5th Asian Pain Symposium、2013.12.18-20 (Okazaki)

So K, Zhao M, Nakamura S, Shirakawa H, Nakagawa T, Kaneko S
「Redox-sensitive TRPA1 is involved in dysesthesia induced by transient hindlimb ischemia-reperfusion in mice」
The 5th Asian Pain Symposium、2013.12.18-20 (Okazaki)

Dogishi K, Homan T, Kodera M, Tsuzuki T, Shirakawa H, Nakagawa T, Kaneko S
「Behaviors associated with pain in mice model of chronic inflammatory and overactive bladder by intravesical injection of hydrogen peroxide」
The 5th Asian Pain Symposium、2013.12.18-20 (Okazaki)

Isami K, Haraguchi K, Asakura K, So K, Shirakawa H, Oyama T, Nakagawa T, Kaneko S
「Peripheral nerve injury-induced infiltration of bone marrow-derived cells into the spinal cord in neuropathic pain: roles of TRPM2」
The 5th Asian Pain Symposium、2013.12.18-20 (Okazaki)

Shirakawa H, Munakata M, Miyanohara J, Miyake T, Nakagawa T, Kaneko S.
「The TRPC3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice」
Neuroscience2013 （the 43th Annual Meeting of the Society for Neuroscience）、2013.11.9-13（San Diego）

Sakimoto S, Shirakawa H, Asakura K, Munakata M, Nakagawa T, Kaneko S.
「TRPM2-mediated NO production in microglia/macrophage contribute to the progression of cerebral ischemic injury in mice」
Neuroscience2013 （the 43th Annual Meeting of the Society for Neuroscience）、2013.11.9-13（San Diego）

2012年

Kaneko S, Haraguchi K, Isami K, Shirakawa H, Nakagawa T.
「The Role of TRPM2 channel in inflammatory and neuropathic pain」
Neuroscience2012 （the 42th Annual Meeting of the Society for Neuroscience）、2012.10.13-17（New Orleans）

Zhao M, Shirakawa H, Nakagawa T, Kaneko S.
「Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by enhanced responsiveness of TRPA1 in mice」
Neuroscience2012 （the 42th Annual Meeting of the Society for Neuroscience）、2012.10.13-17（New Orleans）

Kaneko S, Haraguchi K, Shirakawa H, Nakagawa T.
「TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice」
14th Word Congress on Pain (International Association for the Study of Pain (IASP) 2012)、2012.8.27-31 (Milan, Italy)

Nakagawa T, Zhao M, Shirakawa H, Kaneko S.
「Involvement of TRPA1 in acute cold hypersensitivity characteristically induced by oxaliplatin in mice」
14th Word Congress on Pain (International Association for the Study of Pain (IASP) 2012)、2012.8.27-31 (Milan, Italy)

2011年

Shirakawa H, Konno M, Munakata M, Sakimoto S, Nakagawa T, Kaneko S.
「Functional coupling of TRPC1 and TRPC3 in thrombin-induced astrocyte activation」
Neuroscience2011 (the 41th Annual Meeting of the Society for Neuroscience)、2011.11.12-16 (Washington, DC)

Konno M, Shirakawa H, Iida S, Sakimoto S, Nakagawa T, Shibasaki K, Kaneko S.
「Stimulation of TRPV4 channel suppresses aberrant activation of microglia induced by lipopolisaccharide」
The 6th SKO Symposium、2011.6.2-3 (Seoul, Korea)

2010年

Nagayasu K, Kitaichi M, Shirakawa H, Nakagawa T, Kaneko S.
「Sustained exposure to selective serotonin reuptake inhibitors induces the augmentation of serotonin release in organotypic raphe slice cultures」
Neuroscience2010 (the 40th Annual Meeting of the Society for Neuroscience)、2010.11.13-17 (San Diego, CA)

Nakagawa T, Kawamoto A, Haraguchi K, Maeda S, Shirakawa H, Mori Y, Kaneko S.
「Involvement of TRPM2 expressed in macrophage in inflammatory pain」
13th Word Congress on Pain (International Association for the Study of Pain (IASP) 2010)、2010.8.29-9.2 (Montreal, Quebec, Canada)

Haraguchi K, Nakagawa T, Kawamoto A, Maeda S, Shirakawa H, Mori Y, Kaneko S.
「Critical role of TRPM2 in murine models of neuropathic pain」
13th Word Congress on Pain (International Association for the Study of Pain (IASP) 2010)、2010.8.29-9.2 (Montreal, Quebec, Canada)

Shirakawa H, Nakagawa T, Kaneko S.
「TRPC3 mediates thrombin-induced astrocyte activation and upregulates its own expression in rat cortical astrocytes」
WorldPharma2010 (16th World Congress on Basic and Clinical Pharmacology)、2010.7.17-23（Copenhagen, Denmark）

2009年

Shirakawa H, Konno M, Matsutani I, Nakagawa T, Kaneko S.
「Pathophysiological role of TRPV4 in the process of microglial activation」
Neuroscience2009 (SfN 39th Annual Meeting)、2009.10 (Chicago, IL)

Nakagawa T, Higuchi M, Nagayasu K, Suzuki Y, Yatani Y, Shirakawa H, Kaneko S.
「Mechanisms of serotonergic sensitization induced by sustained MDMA exposure in rat organotypic mesencephalic slice cultures」
IUPS2009 (XXXVI th International Union of Physiological Sciences)、2009.7 (Kyoto)

Shirakawa H, Matsutani I, Konno M, Kusano A, Nakagawa T, Kaneko S.
「Involvement of TRPV4 in the process of microglial activation」
IUPS2009 (XXXVI th International Union of Physiological Sciences)、2009.7 (Kyoto)

2008年

Maeda S, Kawmoto A, Yatani Y, Nakagawa T, Kaneko S.
「Roles of spinal GLT-1, a glial glutamate transporter, in the pathogenesis of inflammatory and neuropathic pain」
The 4th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists、2008.4 (Kyoto)

2007年

Shirakawa H, Yamaoka T, Sanpei K, Nakagawa T, Kaneko S.
「TRPV1 mediates neurotoxicity induced by Gq-coupled receptor agonists at slightly low pH」
Neuroscience2007 (SfN 37th Annual Meeting)、2007.11（San Diego, CA）

Nakao K, Sugishita A, Matsutani I, Nakagawa T, Shirakawa H, Kaneko S.
「Ca²⁺ mobilization mediated by transient receptor potential canonical 1 is associated with thrombin-induced morphological changes of 1321N1 human astrocytoma cells」
Neuroscience2007 (SfN 37th Annual Meeting)、2007.11（San Diego, CA）

Deyama S, Katayama T, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M.
「Role of the protein kinase A activation within the bed nucleus of the stria terminalis in pain-induced aversion in rats」
Neuroscience2007 (SfN 37th Annual Meeting)、2007.11（San Diego, CA）

2006年

Nakagawa T, Wakamatsu K, Zhang N, Maeda S, Satoh M, Kaneko S.
「Activation of spinal P2X-receptors produce long-lasting allodynia in rats: roles of spinal glial cells」
Neuroscience2006 (SfN 36th Annual Meeting)、2006.10（Atlanta）

Minami M, Deyama S, Akiyama N, Hirata M, Nakagawa T, Kaneko S.
「Noradrenergic transmission within the bed nucleus of the stria terminalis contributes to the negative affective component of pain in rats」
Neuroscience2006 (SfN 36th Annual Meeting)、2006.10（Atlanta）

Deyama S, Takishita A, Nakagawa T, Tanimoto S, Kaneko S, Satoh M, Minami M.
「Noradrenergic transmission within the central amygdaloid nucleus contributes to the negative affective component of visceral pain in rats」
Serotonin Club-Sixth IUPHAR Satellite Meeting on Serotonin, 2006.6 (Hokkaido)

Hirata M, Deyama S, Akiyama N, Nakagawa T, Kaneko S, Minami M.
「Role of noradrenergic transmission within the bed nucleus of the stria terminalis in somatic pain-related aversion in rats」
Serotonin Club-Sixth IUPHAR Satellite Meeting on Serotonin, 2006.6 (Hokkaido)

Akiyama N, Deyama S, Hirata M, Nakagawa T, Kaneko S, Minami M.
「Role of noradrenergic transmission within the bed nucleus of the stria terminalis in visceral pain-related aversion in rats」
Serotonin Club-Sixth IUPHAR Satellite Meeting on Serotonin, 2006.6 (Hokkaido)

2005年

Nakagawa T, Fujio M, Suzuki Y, Satoh M, Kaneko S.
「Glial glutamate transporter GLT-1 plays an inhibitory role in the conditioned rewarding effects of morphine and psychostimulants」
Neuroscience2005 (SfN 35th Annual Meeting)、2005.11（Washington DC）

Shimamoto K, Otsubo Y, Hirose T, Shigeri Y, Nakagawa T.
「Characterization of the radioisotope labeled analog of L-threo-β-benzyloxyaspartate (TBOA) binding to glutamate transporters」
Neuroscience2005 (SfN 35th Annual Meeting)、2005.11（Washington DC）

2004年

Minami M, Nakagawa T, Takishita A, Tanimoto S, Kaneko S, Satoh M.
「Roles of the noradrenergic neurotransmission at the amygdaloid nuclei in pain-related aversion」
Neuroscience2004 (34th Annual Meeting of Society for Neuroscience)、2004.10 (SanDiego, CA)

Nakagawa T, Fujio M, Suzuki Y, Ozawa T, Sekiya Y, Minami M, Kaneko S. and Satoh, M.
「Roles of a glial glutamate transporter GLT-1 in drug dependence」
INRC2004 (35th Annual Meeting of International Narcotics Research Conference)、2004.7（Kyoto）

Fujio M, Yamamoto R, Nakagawa T, Minami M, Kaneko S, Satoh M.
「A role of the extended amygdala in the negative affective component of morphine withdrawal in rats」
INRC2004 (35th Annual Meeting of International Narcotics Research Conference)、2004.7（Kyoto）

Nakagawa T, Satoh M.
「Roles of a glial glutamate transporter GLT-1 in morphine dependence」
The IIIrd Meeting of Asian Pacific Opioid Symposium on Molecular Basis of Opioid Tolerance and Dependence、2004.7（Kyoto）

2003年

Minami M, Yamamoto J, Machida T, Tanimoto S, Nakagawa T, Satoh M.
「Inhibition of glutamatergic transmission by morphine in the basolateral amygdaloid nucleus reduces the aversive response induced by noxious stimuli」
Neuroscience 2003（Society for Neuroscience 33rd Annual Meeting）、2003.11（New Orleans, LA）

Nakagawa T, Satoh M.
Symposium『Cellular and Molecular Basis of Opioid Dependence』「Involvement of glial glutamate transporters in morphine dependence」
The International Society for Neurochemistry/Asian Pacific Society for Neurochemistry Sponsored Satellite Meeting、2003.9（Kyoto）

Nakagawa T, Ozawa T, Sekiya Y, Minami M, Satoh M.
「Involvement of GLT-1, a glial glutamate transporter, in physical and psychological morphine dependence」
INRC2003 (34th Annual Meeting of International Narcotics Research Conference)、2003.7（Perpignan, France）

Nakagawa T, Ozawa T, Sekiya Y, Minami M, Satoh M.
「Effects of gene transfer of GLT-1, a glutamate transporter, into the locus coeruleus or nucleus accumbens shell by recombinant adenovirus on physical and psychological morphine-dependence in rats」
The 4th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects、2003.5（Fukui）

2002年

Satoh M, Minami M, Nakagawa T, Fukui M, Okada M.
「The roles of P2 purinergic receptors in nociception and antinociception」
China-Japan Joint Congress on Toxicology and Pharmacology、2002.12（Shenzhen, China）

Fukui M, Takishita A, Nakagawa T, Minami M, Satoh M.
「Antinociceptive effects of P2X purinoceptor agonists in rat brain: an involvement of noradrenergic neurons arising from the locus coeruleus」
10th World Congress on Pain：The International Association for the Study of Pain (IASP) 、2002.8（SanDiego, USA）

Nakagawa T, Watanabe T, Yamamoto R, Minami M, Satoh M.
「Role of the central nucleus of amygdala in morphine withdrawal-induced conditioned place aversion in rats」
INRC2002 (The International Narcotics Research Conference), 2002.7（Monterey, CA, USA）

2001年

Nakagawa T, Ozawa T, Shige K, Yamamoto R, Minami M, Satoh M.
「Involvement of glial glutamate transporters in morphine dependence and naloxone-precipitated withdrawal」
INRC2001 (The International Narcotics Research Conference), 2001.7（Helsinki, Finland）

1998年

Nakagawa T, Minami M, Watanabe T, Ozawa T, Satoh M.
「Study on the molecular mechanism for supersensitization of adenylyl cyclase system in colned opioid receptor-transfected CHO cells following chronic opioid treatment」
XIIIth International Congress of Pharmacology、1998.7（Munchen, Germany）

Nakagawa T, Minami M, Watanabz T, Ozawa T, Satoh M.
「A molecular mechanism for supersensitization of adennylyl cyclase system following sustained stimulation of opioid receptor」
29th Meeting of the International Narcotics Research Conference、1998.7（Garmisch-Partenkirchen, Germany）

Nakagawa T, Masuda T, Minami M, Satoh M.
「A possible mechanism of inhibitory effect of PGE receptor EP3-subtype selective agonists on naloxone-precipitated withdrawal in morphine dependent rats」
29th Meeting of the International Narcotics Research Conference、1998.7（Garmisch-Partenkirchen, Germany）